abstract：:Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the aim ...

journal_title：Neuroscience

authors： Winther G,Elfving B,Müller HK,Lund S,Wegener G

更新日期：2018-09-15 00:00:00

abstract：:Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNN expression around somas, proximal d...

journal_title：Neuroscience

authors： Chu P,Abraham R,Budhu K,Khan U,De Marco Garcia N,Brumberg JC

更新日期：2018-09-15 00:00:00

abstract：:Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either s...

journal_title：Neuroscience

authors： Kent M,Scott S,Lambert S,Kirk E,Terhune-Cotter B,Thompson B,Neal S,Dozier B,Bardi M,Lambert K

更新日期：2018-08-21 00:00:00

abstract：:PACAP1-38, a ubiquitous and multifunctional regulator has been in the focus of neurotoxicity research due to its impressive neuroprotective potential. Although the literature extensively demonstrated its repressive effect on the apoptotic machinery in neurodegenerative models, there is a striking absence of analysis o...

journal_title：Neuroscience

authors： Nyisztor Z,Denes V,Kovacs-Valasek A,Hideg O,Berta G,Gabriel R

更新日期：2018-08-10 00:00:00

abstract：:Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, su...

journal_title：Neuroscience

authors： Meyer M,Lara A,Hunt H,Belanoff J,de Kloet ER,Gonzalez Deniselle MC,De Nicola AF

更新日期：2018-08-01 00:00:00

abstract：:The sodium-activated potassium channel Slack (Slo2.2) is widely expressed in central and peripheral neurons where it is supposed to shape firing properties important for neuronal excitability. Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decre...

journal_title：Neuroscience

authors： Bausch AE,Ehinger R,Straubinger J,Zerfass P,Nann Y,Lukowski R

更新日期：2018-08-01 00:00:00

abstract：:Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy se...

journal_title：Neuroscience

authors： Shakya M,Shrestha PK,Briski KP

更新日期：2018-07-15 00:00:00

abstract：:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during ...

journal_title：Neuroscience

authors： Meier L,Federspiel A,Jann K,Wiest R,Strik W,Dierks T

更新日期：2018-07-15 00:00:00

abstract：:Recent studies have revealed that the ventral premotor cortex (PMv) of nonhuman primates plays a pivotal role in various behaviors that require the transformation of sensory cues to appropriate actions. Examples include decision-making based on various sensory cues, preparation for upcoming motor behavior, adaptive se...

journal_title：Neuroscience

authors： Kurata K

更新日期：2018-07-01 00:00:00

abstract：:Brain structural connectivity is known to be altered in cases of intrauterine growth restriction and premature birth, although the specific effect of maternal nutritional restriction, a common burden in human populations, has not been assessed yet. Here we analyze the effects of maternal undernutrition during pregnanc...

journal_title：Neuroscience

authors： Barbeito-Andrés J,Gleiser PM,Bernal V,Hallgrímsson B,Gonzalez PN

更新日期：2018-06-01 00:00:00

abstract：:Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system. We investigated the role of the XCL1-XCR1...

journal_title：Neuroscience

authors： Bird EV,Iannitti T,Christmas CR,Obara I,Andreev VI,King AE,Boissonade FM

更新日期：2018-05-21 00:00:00

abstract：:Extensive studies have shown that a sports expert is superior to a sports novice in visually perceptual-cognitive processes of sports scene information, however the attentional and neural basis of it has not been thoroughly explored. The present study examined whether a sport expert has the attentional superiority on ...

journal_title：Neuroscience

authors： He M,Qi C,Lu Y,Song A,Hayat SZ,Xu X

更新日期：2018-05-21 00:00:00

abstract：:Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes ope...

journal_title：Neuroscience

authors： Qin P,Duncan NW,Chen DY,Chen CJ,Huang LK,Huang Z,Lin CE,Wiebking C,Yang CM,Northoff G,Lane TJ

更新日期：2018-05-21 00:00:00

abstract：:An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to exa...

journal_title：Neuroscience

authors： Rizzo FR,Federici M,Mercuri NB

更新日期：2018-05-01 00:00:00

abstract：:Epigenetic modulation participates in the mechanism of multiple types of pathological pain, so targeting the involved regulators may be a promising strategy for pain treatment. Our previous research identified the analgesic effect of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) on mechanical hyperalge...

journal_title：Neuroscience

authors： Hou X,Weng Y,Wang T,Ouyang B,Li Y,Song Z,Pan Y,Zhang Z,Zou W,Huang C,Guo Q

更新日期：2018-05-01 00:00:00

abstract：:Chronic Mountain Sickness (CMS) occurs in high-altitude residents with major neurological symptoms such as migraine headaches, dizziness and cognitive deficits. Recent work demonstrated that highlanders have increased intracellular pH (pHi) in their brain cells, perhaps for the sake of adaptation to hypoxemia and help...

journal_title：Neuroscience

authors： Yao H,Zhao H,Wang J,Haddad GG

更新日期：2018-04-01 00:00:00

abstract：:Alternative motor responses can be prepared in parallel. Here, we used electroencephalography (EEG) to test whether the parallel preparation of alternative response options is modulated by their relative value. Participants performed a choice response task with three potential actions: isometric contraction of the lef...

journal_title：Neuroscience

authors： Reuter EM,Marinovic W,Beikoff J,Carroll TJ

更新日期：2018-03-15 00:00:00

abstract：:Affective states, such as anticipatory anxiety, critically influence speech communication behavior in adults who stutter. However, there is currently little evidence regarding the involvement of the limbic system in speech disfluency during interpersonal communication. We designed this neuroimaging study and experimen...

journal_title：Neuroscience

authors： Toyomura A,Fujii T,Yokosawa K,Kuriki S

更新日期：2018-03-15 00:00:00

abstract：:Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditio...

journal_title：Neuroscience

authors： Takai Y,Kawai M,Ogo T,Ichinose T,Furuya S,Takaki N,Tone Y,Udo H,Furuse M,Yasuo S

更新日期：2018-03-15 00:00:00

abstract：:Cerebral ischemia is the most common cause of stroke with high morbidity, disability and mortality. Sirtuin-2 (Sirt2), a vitally important NAD+-dependent deacetylase which has been widely researched in central nervous system diseases, has also been identified as a promising treatment target using its specific inhibito...

journal_title：Neuroscience

authors： Wu D,Lu W,Wei Z,Xu M,Liu X

更新日期：2018-03-15 00:00:00

abstract：:Toll-like receptor 2 (TLR2) and TLR4 belong to a family of highly conserved pattern recognition receptors and are well-known upstream sensors of signaling pathways of innate immunity. TLR2 and TLR4 upregulation is thought to be associated with poor outcome in stroke patients. We currently show that transient focal isc...

journal_title：Neuroscience

authors： Nalamolu KR,Smith NJ,Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

更新日期：2018-03-01 00:00:00

abstract：:'Significant' objects contribute greatly to scene recognition. The lateral occipital complex (LOC), parahippocampal place area (PPA), and retrosplenial cortex (RSC) play a crucial role in the cognitive processing of objects and scenes. However, the associated mechanism between objects and scenes remains unclear. In th...

journal_title：Neuroscience

authors： Wang S,Cao L,Xu J,Zhang G,Lou Y,Liu B

更新日期：2018-02-21 00:00:00

abstract：:In a complex linguistic environment, while speech sounds can greatly vary, some shared features are often invariant. These invariant features constitute so-called abstract auditory rules. Our previous study has shown that with auditory sensory intelligence, the human brain can automatically extract the abstract audito...

journal_title：Neuroscience

authors： Guo XT,Wang XD,Liang XY,Wang M,Chen L

更新日期：2018-02-21 00:00:00

abstract：:Conventional extracellular recording has revealed cross-modal alterations of auditory cell activities by cutaneous electrical stimulation of the hindpaw in first- and higher-order auditory thalamic nuclei (Donishi et al., 2011). Juxta-cellular recording and labeling techniques were used in the present study to examine...

journal_title：Neuroscience

authors： Kimura A,Imbe H

更新日期：2018-02-21 00:00:00

abstract：:Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-...

journal_title：Neuroscience

authors： Jijón-Lorenzo R,Caballero-Florán IH,Recillas-Morales S,Cortés H,Avalos-Fuentes JA,Paz-Bermúdez FJ,Erlij D,Florán B

更新日期：2018-02-21 00:00:00

abstract：:Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signaling activation, leading to repression of proneural factors such as Mash1 and Ngn2/3, which are essential for neuronal different...

journal_title：Neuroscience

authors： Lemes SF,de Souza ACP,Payolla TB,Versutti MD,de Fátima da Silva Ramalho A,Mendes-da-Silva C,Souza CM,Milanski M,Torsoni AS,Torsoni MA

更新日期：2018-02-10 00:00:00

abstract：:Long-term unilateral hearing impairment (UHI) results in changes in hearing and psychoacoustic performance that are likely related to cortical reorganization. However, the underlying functional changes in the brain are not yet fully understood. Here, we studied alterations in inter- and intra-hemispheric resting-state...

journal_title：Neuroscience

authors： Zhang Y,Mao Z,Feng S,Liu X,Zhang J,Yu X

更新日期：2018-02-10 00:00:00

abstract：:Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...

journal_title：Neuroscience

authors： Chang IA,Kim KJ,Namgung U

更新日期：2018-02-10 00:00:00

abstract：:The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functioning, and the oxidant and antioxidant capacity of plasma. We recruited 52 healthy s...

journal_title：Neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Patruno A,Ballerini P,De Lutiis MA,Felaco M,Grilli A

更新日期：2018-02-01 00:00:00

abstract：:Astrocytes have been generally believed to perform mainly homeostatic and supportive functions for neurons in the central nervous system. Recently, a growing body of evidence suggests previously unrecognized and surprising functions for astrocytes, including regulation of synaptic formation, transmission and plasticit...

journal_title：Neuroscience

authors： Adamsky A,Goshen I

更新日期：2018-02-01 00:00:00

abstract：:Fetal alcohol spectrum disorder is associated with defects in neuronal generation, migration, and differentiation. The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Wild-type and Bax knockout mice were g...

journal_title：Neuroscience

authors： Britton SM,Miller MW

更新日期：2018-01-15 00:00:00

abstract：:Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phosph...

journal_title：Neuroscience

authors： Yoshida R,Takai S,Sanematsu K,Margolskee RF,Shigemura N,Ninomiya Y

更新日期：2018-01-15 00:00:00

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervat...

journal_title：Neuroscience

authors： Bale MR,Maravall M

更新日期：2018-01-01 00:00:00

abstract：:The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-da...

journal_title：Neuroscience

authors： Burnham NW,Thiele TE

更新日期：2017-12-26 00:00:00

abstract：:In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral sclerosis that, in its bulbar form, is manifested...

journal_title：Neuroscience

authors： Ghezzi F,Monni L,Corsini S,Rauti R,Nistri A

更新日期：2017-12-26 00:00:00

abstract：:Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during t...

journal_title：Neuroscience

authors： Hueston CM,Cryan JF,Nolan YM

更新日期：2017-12-04 00:00:00

abstract：:Development of functional synapses is crucial for the transmission and storage of information in the brain. Post establishment of the initial synaptic contact, synapses are stabilized through neuronal activity-induced signals. Emerging studies have implicated ubiquitination; a reversible posttranslational modification...

journal_title：Neuroscience

authors： Kumari P,Srinivasan B,Banerjee S

更新日期：2017-11-19 00:00:00

abstract：:Stress during early development produces lasting effects on psychopathological outcomes. We analysed the impact of prior intermittent, physical stress (IPS) during early adolescence (PD 22-33) on anxiety-like behaviour of female rats in adulthood. After behavioural testing, we used immunohistochemistry for the 5-HT tr...

journal_title：Neuroscience

authors： Tao CS,Dhamija P,Booij L,Menard JL

更新日期：2017-11-19 00:00:00

abstract：:The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons is a multistep process, and the transition is finely regulated by transcription factors with basic helix-loop-helix (bHLH) motifs. Melatonin is an endogenous neurohormone with profound neurotrophic and neuroprotective effects...

journal_title：Neuroscience

authors： Li X,Chen X,Zhou W,Ji S,Li X,Li G,Liu G,Wang F,Hao A

更新日期：2017-11-19 00:00:00